It could be a classing case of “buy low, sell high” when the Clemson Tigers visit the Louisville Cardinals. Yes, Clemson is 2-0 while winning by a combined score of 90-20 while Louisville is 0-2 after getting upset here at home by Houston out of the AAC on Saturday. However, Clemson has beaten a couple of cupcakes in Wofford and Appalachian State and now steps up in class in its ACC opener while going on the road for the first time at a difficult environment, especially at night. That seems to make the Tigers vulnerable road favorites. Louisville meantime was simply caught in sandwich game vs. Houston as that contest was wedged between two games vs. ranked opponents. And the Cardinals covered the spread in a 31-24 loss to Auburn on a neutral field to open the season. Louisville is 10-3 ATS in its last 13 games following a straight up loss.
Pick: Louisville +6½ (-115)