The defending champion Florida State Seminoles have won 23 straight games and are ranked second, but both that winning streak and their Playoff hopes could be in jeopardy when they visit the Louisville Cardinals. Louisville has the best defense in the land, leading the nation in total defense, raw defensive efficiency and DFEI, which is schedule-adjusted efficiency. So the Noles do not figure to score their usual share of points and may have to rely on defense to win, and that unit is down to 53rd in total defense after losing so much talent from the defense that was third in that category last season. And the Louisville offense is finally healthy with quarterback Will Gardner and wide receiver DeVante Parker back from injury and Michael Dyer running like he did at Auburn again. Florida State is 0-7 ATS its last seven games after allowing more than 450 total yards its previous game.
Pick: Louisville +4½